In addition, the effect seen in psoriatic skin lesions could be reproduced in cell culture experiments by stimulation of keratinocytes with IL-22 (10 ng/ml), oncostatin M (OSM) (25 ng/ml), IL-17 (25 ng/ml), and TNFα (10 ng/ml) (psoriasis like conditions) which resulted in diminished GATA3 expression when compared to non-stimulated (ns) conditions (by trend) and significantly less GATA3 expression when compared to AD like conditions (p = 0,0003, Holm-Sidak method) (Fig. 1C). This evidence concerns the gene GATA3 and psoriasis.