Human primary keratinocytes stimulated with IL-4 and IL-13 (AD like conditions) showed a significant increase in GATA3 expression (p = 0,002, Holm-Sidak method) similar to the results obtained by immunohistochemical staining for the basal and suprabasal layers of lesional skin from AD patients depicted in Fig. 1A. This evidence concerns the gene IL13 and Alzheimer disease.