In agreement with our hypothesis, ATRA-induced differentiation and eventual death of malignant APL blasts resulted in a normalization of PGD2 levels, as well as a complete restoration of all downstream mediators of the pathway (i.e., ILC2s, NKp30, IL-13, M-MDSCs, T-cell effector functions). Here, NCR3 is linked to acute promyelocytic leukemia.