CA2 and Alzheimer disease: After stimulation with Th2-cytokines (IL-4 and IL-13), we observed a minor decrease (only statistically significant for FLG) in FLG, LOR and IVL expression in N/TERT keratinocytes (Fig. 3C), while markers for AD, C-C motif chemokine ligand 26 (CCL26) and carbonic anhydrase 2 (CA2)30,36, were found to be upregulated (Fig. 3D).