We also identified a significant association between mumps and a variant on chromosome 14 (rs11160318, P = 4.56 × 10−12, OR = 1.1) that is located in the intergenic region upstream of BDKRB2. The role of BDKRB2 in mumps susceptibility is not clear, but the BDKRB2 product has high affinity for intact kinins, which mediate a wide spectrum of biological effects including inflammation, pain, vasodilation, and smooth muscle contraction and relaxation22. This evidence concerns the gene BDKRB2 and mumps infectious disease.