Significant differences between the HCC (n = 142) and non-HCC groups (n = 575) were observed in age, sex, aspartate transaminase (AST), alanine transaminase (ALT), platelet count, percentage of prothrombin time (PT%), albumin, and AFP (p < 0.0001) but not in HCV viral load or the IL28B or ITPA SNP. This evidence concerns the gene IFNL3 and hepatocellular carcinoma.