DEPDC5 and hepatocellular carcinoma: An intronic single nucleotide polymorphism (SNP) in the DEPDC5 locus on chromosome 22 is associated with HCC risk6, and another SNP, rs2596542, which is located 4.7 kb upstream of the major histocompatibility complex (MHC) class I-related chain A (MICA) gene, is also associated with HCC7.