Comparing AS1411 (DNA based, 26 bp, MW: 8272.41 g/mol42) with other aptamers which are similar in terms of performance (targeting cancer cells), such as MUC1 (DNA based, 72 bp, MW: 22353.64 g/mole and affinity (Kd): 47.3 nM43) and PSMA A10 (RNA based, 56 bp, MW: 17966.62 g/mole and Affinity (Kd): 20.5 nM44) aptamers which were engaged in the studies before38,45,46, the smaller size, DNA base, Guanine-rich, quadraplex structure and expanded range of target cells for AS1411 aptamer made it more than suitable to be used as a targeting agent. Here, FOLH1 is linked to cancer.