NUCLEOLIN and cancer: AS1411 aptamer is a 26 bp single stranded DNA oligonucleotide with high affinity and specificity to a putative surface biomarker, nucleolin, which is an overexpressed protein on numerous cancer cells regardless of tissue origin29,30, such as breast, colon, lung, prostate, gastric, etc. Nucleolin major role is in controling of cell proliferation, apoptosis and promoting cell-survival.