FOLH1 and Familial prostate cancer: In 2004, Farokhzad et al. 38 have published first report of a new bio-conjugate which consisted of poly (lactic acid)-block-polyethylene glycol (PEG) co-polymer with a terminal carboxylic acid functional group (PLA-PEG-COOH nanoparticle) and A10 PSMA aptamer (RNA aptamer) which specifically binds to prostate-specific membrane antigen, an overexpressed transmembrane on prostate cancer epithelial cells.