The similar increase in serum Hsp70 and Hsp90 in the two different cancer cachexia models reveals that diverse types of cachexia-inducing tumor cells release high levels of Hsp70 and Hsp90, and cancer cachexia co-exists with elevated circulating Hsp70 and Hsp90, suggesting a potential role for the two HSPs in cancer cachexia. This evidence concerns the gene HSP90AB1 and neoplasm.