Furthermore, we observed elevated release of Hsp70 and Hsp90 into culture media by other prominent cachexia-inducing tumor cells of mouse or human origin, as well as in the serum of two complementary models of cancer cachexia in mice, suggesting a potential role for tumor-generated circulating Hsp70 and Hsp90 in muscle wasting. Here, HSP90AA1 is linked to neoplasm.