HSP90AA1 and neoplasm: Given that a number of tumor cells express high levels of cell surface Hsp70/9014–17 and release EVs expressing surface Hsp70/9018–21 that cause systemic inflammation as danger-associated molecular patterns (DAMPs)22, we tested the hypothesis that tumor cells induce muscle wasting by releasing high levels of extracellular Hsp70 and Hsp90.