In addition, C/EBPβ-regulated E3 ubiquitin ligases atrogin1 (MAFbx) and UBR2 (E3α-II), rather than FoxO1/3-regulated E3 MuRF1, are consistently upregulated in cachectic muscle of tumor-bearing mice4, 9, 10. This evidence concerns the gene UBR2 and neoplasm.