To determine whether the capacity of tumor to induce muscle wasting depends on its expression of Hsp70 and Hsp90 we knocked down Hsp70 and/or Hsp90 expression in LLC cells with siRNA (Supplementary Fig. 6A), which blocked high-level release of Hsp70 and Hsp90 by these cells (Supplementary Fig. 6B). Here, HSP90AB1 is linked to neoplasm.