Further, serum levels of Hsp70 and Hsp90α in Apcmin/+ mice that developed cachexia chronically due to intestinal adenoma caused by the Apcmin/+ mutation at 20-week of age9 were elevated ~3–4-fold but not at the pre-cachectic stage of 12-week of age (Fig. 1b). Here, HSP90AA1 is linked to Cachexia.