Our results showed that miR-424 expressed at low levels in infantile skin hemangioma tissues and was negatively correlated with the expression of FGFR1; miR-424 overexpression downregulated the expression of FGFR1 in HemECs, while miR-424 inhibition upregulated FGFR1 expression. This evidence concerns the gene FGFR1 and skin hemangioma.