We next examined the associations of CISD2 expression with other clinicopathological features, and found that CISD2 mRNA expression was significantly correlated with tumor stage, grade of differentiation, or smoking status in several datasets (Supplementary Fig. S1C and D), suggesting that the transcript level of CISD2 might also be clinically relevant to cancer progression. The gene discussed is CISD2; the disease is neoplasm.