After 6 weeks of cancer cell inoculation, we measured p53+/+ tumor loads and found that they were much smaller than p53−/− tumor loads (Fig. 6c) and that p53+/+ tumor burdens were significantly decreased not only by treatment with Oligo-Fucoidan or etoposide alone but also further suppressed by combination treatment with both agents. This evidence concerns the gene TP53 and neoplasm.