TP53 and neoplasm: We found that p53+/+ tumors exhibited less numbers of M2 macrophages accumulated in the microenvironment than p53−/− tumors displayed highly enriched M2 macrophages, whereas Oligo-Fucoidan treatment significantly reduced M2 populations in p53+/+ tumor and particular in p53−/− tumor, revealing that Oligo-Fucoidan can alter the TME development independent of p53 status.