IGF1 and melanoma: In contrast to normal immortalized and fresh NB cells from healthy individuals or melanoma patients, TAB cells produced IGF-1 (Fig. 1d, e), as did fresh TAB (Supplementary Fig. 1a), and a variety of other pro-tumorigenic/pro-inflammatory factors/cytokines including IL-1, VEGF, and PDGF (Supplementary Fig. 1b–g).