Recombinant IGF-1 increased tumor cell expression of FGFR-3 (Fig. 3e) as did co-cultured TAB cells, and reciprocally, recombinant FGF-2 induced IGF-1 production in NB cells (Fig. 3f) as did co-cultured tumor cells (Fig. 2a). Here, IGF1 is linked to neoplasm.