To further support the role of tumor-infiltrating CD20+ B cells in therapy resistance, we compared gene expression array (GSE8401, n = 52) and RNA-seq data (EGAS00001000992, n = 38) from further two independent cohorts of metastatic pre-treatment and treatment-resistant melanoma samples (Supplementary Fig. 11d; Fig. 7f, g). This evidence concerns the gene MS4A1 and neoplasm.