Further, in line with our observation that TAB cells induce drug resistance via IGF-1 (Fig. 5c, d) and activation of the FGFR-3 receptor in tumor cells (Fig. 2b; Fig. 3a, c, e, g), drug resistance of melanoma cells was dependent on the presence of FGFR-3. The gene discussed is IGF1; the disease is neoplasm.