A high expression of hsa_circ_001569 was also observed in CRC tissues, which could act as a sponge to bind to miR-145, and resulted in the up-regulation of target genes of miR-145, including E2F transcription factor 5 (E2F5), BCL2-associated athanogene 4 (BAG4), and formin like 2 (FMNL2), thus playing as a positive regulator in cell proliferation and invasion of the CRC [52]. Here, E2F5 is linked to colorectal carcinoma.