CircZKSCAN1, originated from a zinc finger family gene (ZKSCAN1), was discovered with significantly lower expression in 102 HCC patients by RT-PCR, and the levels influenced in patients by different tumor numbers, cirrhosis, vascular invasion, or microscopic vascular invasion (MVI), as well as the tumor grade, which could co-operate closely with ZKSCAN1 mRNA to inhibit growth, migration, and invasion of HCC [58]. Here, ZKSCAN1 is linked to Cirrhosis.