Meanwhile, it was found that down-regulation of cZNF292 contributed to decreased transcription of E2F transcription factor 1 (E2F1), NF-κB, Sp1 transcription factor (Sp1), hypoxia inducible factor 1 (HIF-1), AP-1 transcription factor subunit (AP-1), signal transducer and activator of transcription 3 (STAT3), and signal transducer and activator of transcription 5 (STAT5), thus inhibiting the tube formation in tumor cells [71,72]. This evidence concerns the gene E2F1 and neoplasm.