Lately, hsa_circ_0000096 was also found to be markedly down-regulated in both GC tissues and GC cell lines relative to the control paired adjacent nontumorous tissues and normal gastric epithelial cells, which may attenuate GC cell growth and migration by regulating cyclin D1, cyclin-dependent kinases6 (CDK6), matrix metalloprotein-2 (MMP-2), and matrix metalloprotein-9 (MMP-9) [48]. This evidence concerns the gene CCND1 and gastric cancer.