Moreover, some studies have reported that circRNAs were concerned with many kinds of human diseases, and were widely involved in numerous physiological and pathological processes, for instance promoting insulin biosynthesis and secretion through the CDR1as/miR-7 pathway, and dysregulation in Alzheimer’s disease (AD), Parkinson’s disease, and cardiovascular diseases [36,42–44]. This evidence concerns the gene INS and Alzheimer disease.