Another circRNA named cir-ITCH (itchy E3 ubiquitin protein ligase), acquired from a total of 684 ESCC and paired adjacent nontumor tissue samples via RT-PCR, which could act as a sponge for miR-7, miR-17, and miR-214, had an inhibitory effect on ESCC by stimulating ITCH levels to promote an ubiquitin-mediated dishevelled segment polarity protein 2 (Dvl2) degradation, suppressing the canonical Wnt/β-catenin [61]. Here, UBE2E3 is linked to esophageal squamous cell carcinoma.