Finally, FUS knockout and knockdown did not lead to the ALS phenotypes, but instead resulted in FTD-like behavioral phenotypes, such as hyperactivity and reduced anxiety-related behavior (Kino et al., 2015, Udagawa et al., 2015), indicating that the loss of FUS function also contributes to the development of FTD phenotypes. Here, FUS is linked to frontotemporal dementia.