In addition, it has been showed that EPC-conditioned media, which contain growth factors (including PDGF, VEGF, HGF, etc), can accelerate diabetic wound healing, and an intravenous injection of EPC-conditioned media can promote angiogenesis and improve neurological outcome after cerebral ischemia in mice (Marrotte et al., 2010; Rosell et al., 2013). Here, VEGFA is linked to Cerebral ischemia.