As reported formerly, SAMSN1 (also known as HACS1/NASH1/SLY2) is widely expressed in hematopoietic tissues, muscle, heart, brain, lung, pancreas, endothelial cells and myelomas, usually acts as an immunoinhibitory adaptor, and plays significant roles in the development and regulation of immunocytes such as B cells, T cells and mast cells in both mouse and human [39]. This evidence concerns the gene SAMSN1 and plasma cell myeloma.