CCR4 and breast cancer: Razmkhah et al. suggested that resident adipose derived stem cells (ASCs) in breast cancer tissue could express IL-4 and the mRNA expression of IL-4, which contributes with IL-10, TGF-b1, CD25 and CCR4, in increasing the metastasis of breast cancer cells and the recruitment of Tregs to protect cancer cells from the host immune response [170].