The proposed mechanism was that E-cadherin is cleaved by cathepsins B, S, and L to initiate loosening of cell–cell contacts, degradation of ECM substrates, and consequently generating pores for cancer dissemination [162, 163].On the other hand, using a Lewis lung cancer model, Yan et al. claimed that IL-4-induced macrophages polarization is probably mediated by SIGN (CD209) expression [164]. This evidence concerns the gene IL4 and cancer.