WNK2 and cancer: We further analyzed the pathway enrichment of target genes influenced by the miRNAs and found that the target genes regulated by upregulated miRNAs were mainly enriched in pathways in cancer, proteoglycans in cancer, mitogen-activated protein kinases (MAPK) signaling pathway, Ras signaling pathway, and signaling pathways regulating pluripotency of stem cells (Fig. 5a).