We show for the first time that circulating CD62E+ MPs level and miR-126-3p content in MPs are abnormal in subjects with different degrees of glucose tolerance; miR-126-3p correlates with markers of endothelial inflammation, such as VCAM-1, plasma antioxidant capacity, and microparticles, well-accepted markers of endothelial dysfunction. This evidence concerns the gene VCAM1 and endothelial dysfunction.