We demonstrated that only circulating CD62E+ MPs levels were significantly increased in T2DM and in PreDM compared to NGT subjects, while the levels of AnnexinV+/CD62E+ MPs and AnnexinV+ MPs were higher in T2DM, but not in PreDM, suggesting only in these patients an increased apoptosis. Here, ANXA5 is linked to type 2 diabetes mellitus.