PreDM and T2DM exhibited a larger population of MPs in quadrant I1 (CD62E+ MPs) than NGT, as well as T2DM showed more positive MPs in quadrant I2 and I4 (respectively AnnexinV+/CD62E+ and AnnexinV+ MPs) compared to NGT and PreDM. Here, ANXA5 is linked to type 2 diabetes mellitus.