To this purpose, we determined: (a) CD62E+ (E-selectin) MPs that are released by the activated endothelium [33, 34]; (b) CD62P+ (P-selectin) MPs that are mainly shed by platelets in response to cell activation, and are involved in inflammation and thrombosis [7, 35, 36]; (c) CD45+ MPs that derive from lymphocytes, and have been associated with the type of subclinical atherosclerotic lesions [37]; and (d) CD142+ (tissue factor) MPs which expression is induced on the surface of damaged or activated endothelial cells [38]. Here, SELP is linked to Atherosclerotic lesion.