Moreover, strong support for the likely interaction of allicin with AT1R was provided by in silico modelling and docking analyses in which this garlic derivative optimally complexes at the same site where typical AT1R inhibitors (losartan, olmesartan) promote hypertension blocking and where an oxygen atom from these compounds could form hydrogen bonds (especially with Arg167), thereby strengthening the receptor-inhibitor interactions and pharmacological effects. The gene discussed is AGTR1; the disease is hypertensive disorder.