Clinical manifestations of aqueous-deficient dry eye in Aire -/- mice share a number of features with SS patients, including CD4 T cell-mediated exocrinopathy that is accompanied by compromised corneal epithelial integrity, reduced tear secretion, and CD4 T cell infiltration of the ocular tissues and exocrine glands [31]. This evidence concerns the gene CD4 and Keratoconjunctivitis sicca.