The phase 2a MinerAlocorticoid Receptor antagonist Tolerability Study (ARTS) indeed confirmed a reduced risk for developing hyperkalemia in patients hospitalized for worsening chronic heart failure treated with finerenone compared with those treated with spironolactone despite comparable reduction of efficacy parameters like the brain natriuretic peptide (BNP), NT-proBNP, and albuminuria [11]. This evidence concerns the gene NR3C2 and Hyperkalemia.