NR3C2 and coronary artery disorder: Notably, overactivation of the MR has also been implicated in vascular remodeling processes following vascular injury in animal studies as well as in coronary artery disease and in-stent restenosis in clinical settings: Aldosterone has not only been shown to promote medial cell proliferation by direct effects on the smooth muscle cell (SMC)-MR, but to be an independent predictor for in-stent restenosis and mortality in patients with coronary artery disease [13–15].