Santamaria P. focused on the pathogenesis of autoimmune DM, especially on the role of regulatory T cells[17] and CD8(+) T cells[18] in the autoimmune process, while Roep B.O. and Peakman M. were both making an impact by studying the homeostasis of auto-reactive T cells and regulatory T cells in T1DM[19,20]. This evidence concerns the gene CD8A and type 1 diabetes mellitus.