RAGE is expressed at the highest baseline level in the lung, and is found in alveolar type epithelial cells, vascular endothelial cells, alveolar macrophages and the smooth muscle cells of the airways.[21, 24] It specifically localizes in the adult lung on the basolateral membrane of alveolar type-1 epithelial cells.[25] Conflicting data exist on the directionality of RAGE and sRAGE expression in lung disease. Here, AGER is linked to lung disorder.