Among these, OTSSP167 is the most potent, with subnanomolar activity against MELK and broad-spectrum efficacy in in vitro and in vivo tumor models of various tissue origins (Chung et al., 2012); these encouraging preclinical results spurred initiation of a clinical trial of this compound for patients with solid tumors (Ganguly et al., 2014). The gene discussed is MELK; the disease is neoplasm.