TP53 and ovarian cancer: In this same line, it is interesting observation that IL‐1β secreted by ovarian cancer cells attenuates the expression of p53 in neighboring CAFs,31 given that cytoplasmic p53 is a known downregulator of autophagy.140 As said before, sustained autophagy (as induced by IL‐2) is necessary for myofibroblasts survival in the stroma.138