BRCA1 and ovarian serous carcinoma: However, these tumors show a very different genetic landscape and behavior: high‐grade serous ovarian carcinomas generally bear TP53 mutations and BRCA1/2 epi‐mutations and are chemosensitive, while low‐grade serous ovarian carcinomas generally bear Ki‐RAS and B‐RAF mutations and are chemoresistant.28, 29, 30