It has been demonstrated that under LPA stimulation, the active fibroblasts express and release the CXC chemokine ligand 12/stromal cell derived factor 1α (SDF‐1α), the Vascular Endothelial Growth Factor (VEGF‐A), and IL‐6, which promote the recruitment of endothelial cells and the angiogenic sprouting in the tumor context.85 These events clearly favor the growth and metastasization of ovarian cancers.86 Finally, CAFs contribute to cancer progression also by suppressing the immune response. This evidence concerns the gene IL6 and cancer.