DIRAS3 and ovarian cancer: This cytokine has been shown to induce the anchorage‐independent growth and the migration and invasion of epithelial ovarian carcinoma cells.23, 125, 126 Very recently, we demonstrated that IL‐6 inhibits basal autophagy in ovarian cancer cells.23 More in detail, IL‐6 downregulates the expression of the GTPase Ras homolog ARH‐I/DIRAS3, which acts as a promoter of BECLIN‐1‐dependent autophagy and as an inhibitor of cell locomotion.23 The bioactive phospholipid LPA is another molecule highly secreted by ovarian cancer cells and found in the plasma and serum of the patients.