DNMT3A and acute myeloid leukemia: Brambati and colleagues developed ddPCR assays for DNA (cytosine-5)-methyltransferase 3A (DNMT3A), isocitrate dehydrogenase 1 (IDH1), and isocitrate dehydrogenase 2 (IDH2) [58], three genes that are commonly mutated in AML and that have been shown to occur early in the course of leukemogenesis [25,58].