Concordantly, partial downregulation of mitotic checkpoint proteins in tumor cell lines produced cancer cell death associated with severe chromosome mis-segregation.3 Moreover, overexpression of cyclin E inducing multipolar divisions and numerous chromosome segregation errors was found to have a significant anti-tumorigenic effect in a mouse model for lung cancer.4 Consequently, the idea of promoting cell death by inducing massive chromosome mis-segregation at mitotic division was proposed as a therapeutic strategy to selectively eliminate actively proliferating tumor cells.5 The gene discussed is CCNE1; the disease is neoplasm.