Therefore, the prognostic association of PD‐L1 positivity with better prognosis in lung HGNET might be explained by the differential gene expression, different genetic mutations, high/low CIMP, DNA methylation degree, YAP1 positivity, SCLC‐like/NSCLC‐like phenotype, or high/low immunogenicity. The gene discussed is YAP1; the disease is non-small cell lung carcinoma.