The inhibition of EMT by secreted frizzled‐related proteins (SFRPs) have been detected in tumour cells.46, 53 Consistent with previous studies, the present results confirmed that the increased expressions of negative regulators of Wnt signalling (SFRP1) and TGFβ signalling (CD109) induced the normal phenotype of the fhRPE‐13A cells, suggesting both pathway co‐participate the regulation of re‐morphogenesis. Here, CD109 is linked to neoplasm.