Furthermore, high-risk neuroblastoma can be classified into different biological subsets based on molecular characterization including MYCN amplification status, c-MYC expression, ALK and ATRX mutations, TERT rearrangements and alternative mechanisms of telomere lengthening (ALT) (Peifer et al. 2015; Valentijn et al. 2015). This evidence concerns the gene MYCN and neuroblastoma.