When comparing individuals (patients and controls) with GCLC high-risk and GCLC low-risk genotypes, SLC7A11 was the most up-regulated gene associated with GCLC high-risk variants, with a 2-fold increase of expression already at basal level (p-value = 1.2,10−5, Fig. 1b). This evidence concerns the gene SLC7A11 and lung giant cell carcinoma.