To confirm the capabilities of our tissues as a high-fidelity model for kinase inhibitor toxicity screening in cardiac tissue, we examined Sunitinib, a VEGFR inhibitor that has been documented to elicit acute coronary symptoms including myocardial infarction (MI), heart failure, and left ventricular dysfunction after prolonged and repeated exposure4,28. This evidence concerns the gene KDR and myocardial infarction.