At 1 week post-immunization (prior to the onset of uveitis), we found a significant reduction in TFF3; and increased S100A8 (NaCl EAU 1w 0.0179 ± 0.0105 vs. NI 0.00172 ± 0.00239, p = 0.002) and Reg3γ(NaCl EAU 1w 346.6 ± 179.1 vs. NI 64.33 ± 48.91, p = 0.0005) gene expression in immunized vs. non-immunized mice (Fig. 5A) thus suggesting subclinical alterations in intestinal homeostasis in the ileum prior to the onset of uveitis. The gene discussed is S100A8; the disease is uveitis.