MAPKAPK2 and neoplasm: Although the overall number of T cells remained similar in MK2ΔCD11c and WT dLN upon LPS + tumour lysate immunization, the ratio of CD8+/CD4+ cells was significantly altered, favouring the priming of CD8+ cytotoxic T lymphocytes (CTLs) upon MK2 knock-out in CD11c+ DCs (Fig. 5a,b).