Tumour-resident DCs exhibited pronounced upregulation of Mapkapk2 by 1.9-fold as compared to splenic DCs and also expressed high levels of Il10, Tgfb1 and Arg1, suggesting robust immunosuppressive activity of these cells within the TME (Fig. 2b and Supplementary Fig. 2a). The gene discussed is MAPKAPK2; the disease is neoplasm.