Among the aforementioned three drugs, telmisartan has been known as an angiotensin II receptor antagonist that can be used to treat hypertension34, chlorpropamide has been known as a sulfonylurea drug that acts by increasing insulin to treat type 2 diabetes mellitus35, and alendronate has been known as a bisphosphonate drug mainly used for treating bone disease, such as osteoporosis and osteogenesis imperfect36, 37. Here, INS is linked to type 2 diabetes mellitus.