The risk allele of rs10895322 in our study is also the same allele that promotes neovascular lesion size in the GWAS of AMD, implying that the risk attributed to rs10895322 in neuroblastoma may be mediated through comparable angiogenesis process that is regulated by MMP20. Our eQTL analysis further indicated that rs10895322 may regulate MMP20 expression specifically in 11q-deletion neuroblastoma cases. Here, MMP20 is linked to age-related macular degeneration.