Overall, these loss-of-function and gain-of-function experiments indicated that NF-κB target genes can be roughly categorized into two subtypes according to their SWI/SNF dependency: in these epithelial tumor cell lines, the IL6 and IL8 genes require the SWI/SNF complex for their activation through NF-κB whereas TNF and ICAM1 do not. The gene discussed is IL6; the disease is neoplasm.