To study HB, a limited number of genetically engineered mouse models exist, in which one of Myc, LIN28B, or Ctnnb1 oncogenes can be induced in the mouse liver (Shachaf et al, 2004; Mokkapati et al, 2014; Nguyen et al, 2014) leading to HB or HCC development. This evidence concerns the gene CTNNB1 and hepatocellular carcinoma.