Interestingly, in HB, large deletions in CTNNB1, which encompass exon 3 and part of exon 4, were reported exclusively in pure fetal tumor histotypes, whereas CTNNB1 mutations in embryonal HB are small mutations confined to exon 3 (Lopez‐Terrada et al, 2009). This evidence concerns the gene CTNNB1 and hemoglobin measurement.