Separately, a modified form of aldesleukin has been developed in which conjugation with 6 releasable polyethylene glycol (PEG) chains results in a moiety (NKTR-214) that provides significant greater tumor exposure with less frequent dosing (relative to aldesleukin) with interesting in vitro activity singly and in combination with immune checkpoint blockade [33]. The gene discussed is IL2; the disease is neoplasm.