Our case had no evidence of chronic gastric infection (such as H. pylori and EBV infection) and the IMT tissue was far from the previous surgical boundary, but ALK was positive in primary IMT tissue and metastatic lymph nodes but not FGPs and colon polyps, so translocation involving ALK at chromosome 2p23 may contribute to the development and progression of IMT but not the formation of FGP and FAP. This evidence concerns the gene ALK and polyp of colon.