There was a trend for an increase in the concentrations of IL-6, IL-10, and MCP-1 at 6–8 h after IV infusion of enadenotucirev in the five patients with CRC in cohort B (data not shown) but, generally, the concentration had returned to the pre-infusion level at the next sample (48 h after dosing). This evidence concerns the gene IL6 and colorectal carcinoma.