APOE and Alzheimer disease: We then searched these variants in FHS eQTL database [44] and found that they were associated with the expression of 70 eGenes; 7 of them were nominally associated with WMH, including ARL17A, SYTL2, PTGDR, POLR2E, MS4A6A, GPR141, and RIN3. Among them, ARL17A was the most significant one and it was associated with SNP rs2732703, which was recently found to be associated with Alzheimer’s disease among individuals without APOE ε4 allele [51].