Recent next-generation genomic analysis of meningiomas revealed additional recurrent mutations in v-akt murine thymoma viral oncogene homolog 1/3 (AKT1/3), phosphoinositide-3-kinase catalytic alpha polypeptide (PIK3CA), smoothened (SMO), homolog of suppressor of fused (SUFU), TNF receptor-associated factor 7 (TRAF7), krupplelike factor 4 (KLF4), SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1), RNA polymerase II subunit A (POLR2A), telomerase reverse transcriptase (TERT) promoter, and BRCA1 associated protein 1 (BAP1) [4–10]. The gene discussed is POLR2A; the disease is meningioma.