There are two isoforms of the COX enzyme: COX-1 is found in most tissues and is constitutively expressed in normal cells, whereas COX-2 is not expressed in healthy tissue but is stimulated by inflammatory cytokines (interleukin-1 beta (IL-1β) and tumor necrosis factor (TNF-α)), growth factors, and tumor promoters [8–11]. Here, TNF is linked to neoplasm.