ACTA1 and colorectal carcinoma: To examine the prognostic significance of myofibroblastic CAFs, tumors from cohorts of patients with HNSCC (oral, n = 260; oropharyngeal, n = 271) and early-stage CRC (n = 56) were immunostained for α-SMA and analyzed as described previously (baseline patient characteristics are shown in Table 1) (5,13).