TGFB1 and Hepatic fibrosis: Consistent with our findings, NOX4 has been shown to play a role in TGF-β-dependent fibroblast-to-myofibroblast transdifferentiation in several normal tissues (27,38–40), and its inhibition has been shown to attenuate pulmonary and liver fibrosis in preclinical mouse models (27,38,41).