Co-injection of HFFF2s transduced with shRNA targeting NOX4 and 5PT cells caused a statistically significant reduction in myofibroblast accumulation (53.2%, 95% CI = 24.1% to 82.2%, P = .01) and tumor growth (37.6%, 95% CI = 6.0% to 69.2%, P = .02) (Figure 4, G–I). The gene discussed is NOX4; the disease is neoplasm.