Many genes in these chromosome lesions, such as EGFR (amp 7p11.2) (Eichler et al., 2010), MET (amp 7q31.2) (Breindel et al., 2013; Lutterbach et al., 2007), KRAS (amp 12p12.1) (Schmid et al., 2009), and CACNA2D2 (del 3p21.31) (Warnier et al., 2015), are known to be related to tumor invasion and metastasis. The gene discussed is CACNA2D2; the disease is neoplasm.