For example, TP53, mutated in 63.81% of the 315 reclassified metastatic samples but only in 20.37% of the 108 reclassified nonmetastatic samples, could induce genomic instability (Negrini et al., 2010), aggravate tumor progression, and promote tumor metastasis (Marchetti et al., 1993; Reichel et al., 1994). The gene discussed is TP53; the disease is neoplasm.