APE1 expression is increased in several cancers such as pancreatic (Jiang et al., 2010), prostate (Kelley et al., 2001), cervical (Xu et al., 1997), gliomas (Bobola et al., 2004), lung (Yoo et al., 2008), bladder (Shin et al., 2015), colon (Lou et al., 2014), and ovarian cancers (Al‐Attar et al., 2010; Zhang et al., 2009), and this increase is associated with resistance to radiation and chemotherapy, leading to poorer patient prognosis (Sharbeen et al., 2015). This evidence concerns the gene APEX1 and cancer.