Similarly, STAT3 has been shown to work with HIF1α in order to activate downstream targets in various cancers (Gariboldi et al., 2010; Pawlus et al., 2014), and we have previously shown that APE1 interacts with both STAT3 and HIF1α under hypoxia (Logsdon et al., 2016). The gene discussed is HIF1A; the disease is cancer.