CCL5 and neoplasm: We hypothesized that after reovirus arriving at the tumor site, reoviral infection can induce tumor lysis, provoking an antitumor immune response; the tumor cells infected by reovirus can secrete RANTES, IL-8,MIP-1α, and MIP-1 β, creating a proinflammatory milieu that elicits a chemotactic response [22].