Both hf-PWV and ba-PWV were associated with elevated serum BNP levels (beta coefficient = 8.3 and 6.4, respectively, both P < 0.01; Fig 1) after using a multi-variable regression model that adjusted for age, gender, BMI, systolic blood pressure, PP, renal function, LVMI, left ventricular ejection fraction (EF), and coronary artery disease (S1 Table). The gene discussed is NPPB; the disease is coronary artery disorder.