Conversely, Fgf21 which improves insulin resistance and reduces lipid accumulation [36] was induced 22.8- and 17.2-fold in male and female mice at 28d, respectively, while Serpina6 (corticosteroid binding globulin; CBG) exhibited an inverted “U”-shaped dose-response in both sexes with 3.4- and 2.1-fold induction in male and female mice, respectively. The gene discussed is SERPINA6; the disease is Insulin resistance.