ZHX2 and B-cell chronic lymphocytic leukemia: The female-specific transcription factor, CUX2, and the expression of other hepatocyte nuclear factors (e.g., Hepatocyte Nuclear Factor 4 α;HNF4α, B-Cell CLL/Lymphoma 6; BCL6, Zinc Fingers and Homeoboxes 2; ZHX2) also influence GHR-JAK2-STAT5 signaling and serves an important role in determining sexually dimorphic xenobiotic metabolism gene expression [19, 20].